![]() Electron microscopy of frozen water and aqueous solutions. Vitrification of pure water for electron microscopy. Helmut Ruska and the visualisation of viruses. Die Sichtbarmachung von pflanzlichem Virus im Übermikroskop. Bakterien und Virus in u¨bermikroskopischer Aufnahme. This article describes the recent advances in the field and critically assesses their relevance for drug discovery as well as discussing at what stages of the drug discovery pipeline cryo-EM can be useful today and what to expect in the near future. These advances have raised hopes that single-particle cryo-EM might soon become an important tool for drug discovery, particularly if they could enable structural determination for 'intractable' targets that are still not accessible to X-ray crystallographic analysis. However, recent technological advances - including the development of direct electron detectors and more effective computational image analysis techniques - are revolutionizing the utility of cryo-EM, leading to a burst of high-resolution structures of large macromolecular assemblies. ![]() Historically, its potential for application in drug discovery has been heavily limited by two issues: the minimum size of the structures it can be used to study and the resolution of the images. Added menu "View:Toolbars:Lock Toolbar".Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical technique that can be used to determine the structure of biological macromolecules and assemblies.Bug fix: Bookmarks menu not clickable under Mac.Fixed display issue of when ad blocker is enabled.Fixed Yahoo email compatibility warning.Added support for editing title of the quick-dial buttons on the New Tab page.Disable "startup minimized in system tray" on linux and mac.Bug fix: window position not saved properly on Mac.Bug fix: youtube video download button missing.The quick-search bar gives you instant access to popular search enginesne while also allow you to create/define your own favorite engine. The select-and-translate feature allows you to translate any text within a web page without leaving the page. The popup blocker kills all annoying popup ads before it has chance to disturb you. The site group feature lets you save a collection of web sites as a group and open all of them at once with a single click. Save memory and bandwidth!ĭisplay current weather condition in the status bar of the web browser so that you know what is going on outside all the time. Choose different video quality and resolutions.Įliminates obtrusive advertisements from web pages. ![]() The download manager makes it easy to track and organize your download jobs.ĭownload any youtube video to mp4 or other video formats. You can share a page, a picture or a piece of text on any page on facebook with a single click. SlimBoat also includes tons of powerful functions and flexible options so that you can reach your favorite destination on Internet in the most convenient way while avoiding unnecessary distractions and annoyances.Ĭompletes web form for you automatically and gives you one-click access to your favorite online accounts. SlimBoat helps you surf the internet safely and securely by incorporating multiple layers of protection measures. It is fast to start up and fast to open your favorite web sites. SlimBoat is a free web browser that is fast, secure and loaded with powerful features.
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